Download PDF by M.-F. Schulz-Aellen: Aging and Human Longevity

By M.-F. Schulz-Aellen

ISBN-10: 0817639640

ISBN-13: 9780817639648

ISBN-10: 1461220068

ISBN-13: 9781461220060

The percentage of aged humans maintains to extend within the western world-nearly 1 / 4 of the inhabitants may be over sixty five years through the 12 months 2050. when you consider that getting older is followed by means of a rise in ailments and via a deterioration in health and wellbeing, discovering options to those social, clinical and mental difficulties is inevitably a massive objective for society. Scientists and clinical practitioners are as a result confronted with the pressing activity of accelerating easy wisdom of the organic methods that reason getting older. extra assets needs to be positioned into this examine for you to in attaining greater realizing of the mobile mechanisms that underlie the diversities in lifestyles span among species and to reply to the tough questions of why a few contributors age extra fast than others, and why a few improve liver difficulties, a few have cardiovascular disease, and others mind difficulties. the result of this kind of broad application of study will supply vital information regarding the reasons of many life-threatening and/ or debilitating ailments of previous age; it's going to support locate how one can hinder many of the illnesses that consequence from getting older, and it could actually result in discoveries allowing the prolongation of human life.

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Complete inhibition and abnormal division cycle. MacieiraCoelho (1995) supports the idea of a functional evolution or a drift created by cell division, because it is more compatible with the process of aging observed in vivo: " ... it is not significant for aging to reach an end point, but rather that cells are modified through proliferation so that they become more heterogeneous in their response to growth stimuli, and progress differently through the division cycle". This implies new cell interactions and regulations.

In the presence of ligand, RAR binds to DNA and represses gene expression. Moreover, mac25, a member of the family of insulin-like growth factor binding proteins, also has been found to have tumor suppressive activity. Whereas its expression is down-regulated in mammary carcinoma cell lines, it is stimulated by retinoic acid and has been found to accumulate in senescent cells (Swisshelm et aI, 1995). Thus, the tumor suppressive role of these two proteins may involve a senescent pathway. All the observations made so far in different systems demonstrate the limited capacity of cells from older donors to proliferate in vitro and suggest that cells contain biological clocks that ultimately limit their life span.

The inhibitory role of the primate hippocampus on the hypothalamus has been demonstrated by specific hippocampal lesions that lead to hypercortisolism. Incidentally, in patients with Alzheimer's disease, early neuronal damage is seen in the hippocampus, and the more severe the hippocampal atrophy, the stronger the hypersecretion of cortisol into the bloodstream (De Leon et aI, 1988). Factors That Influence Human Longevity 37 Table 4. Physiological and biochemical processes inhibited by glucocorticoids Immune system: Interferon Natural killer cell activity Interleukin-l Macrophage activating factor Lymphocyte activating factor T-cell growth factor Inflammatory processes: Prostaglandins synthesis Leukotrienes synthesis Bradykinin synthesis Metabolism: Insulin secretion Vasopressin secretion Growth hormone secretion Insulin-like growth factor secretion Amino acid transport and protein synthesis Triglyceride synthesis Glucose transport and glycogen synthesis Calcium transport into bone Hormone secretion: CRF secretion ACTH secretion 13-Endorphin secretion Thromboxane synthesis Gonadal responsiveness to LH (CRF: corticotropin-releasing factor; ACTH: adrenocorticotropic hormone; LH: luteinizing hormone).

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Aging and Human Longevity by M.-F. Schulz-Aellen


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